David H McDermott Selected Research

plerixafor

10/2019	Plerixafor for the Treatment of WHIM Syndrome.
1/2019	Plerixafor for the Treatment of WHIM Syndrome. Reply.
12/2018	Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.
1/2017	Pathogenesis, diagnosis and therapeutic strategies in WHIM syndrome immunodeficiency.
6/2015	CXCR4 antagonist AMD3100 redistributes leukocytes from primary immune organs to secondary immune organs, lung, and blood in mice.
4/2014	A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor.
11/2011	The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome.
10/2011	AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome.
10/2010	Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis.

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David H McDermott Research Topics

Disease

18	WHIM syndrome 01/2022 - 10/2010
7	Infections 01/2021 - 02/2003
5	Neutropenia 10/2019 - 10/2010
5	Inflammation (Inflammations) 01/2019 - 03/2002
4	Primary Immunodeficiency Diseases 10/2019 - 01/2017
3	Warts (Wart) 01/2021 - 04/2014
3	Neoplasms (Cancer) 01/2016 - 04/2014
3	West Nile Fever 01/2010 - 07/2006
2	Agammaglobulinemia (Hypogammaglobulinemia) 01/2021 - 12/2018
2	Cytopenia 10/2019 - 04/2014
2	Chromothripsis 01/2018 - 02/2015
2	Atherosclerosis 08/2011 - 08/2005
2	Disease Progression 01/2010 - 02/2003
1	Virus Diseases (Viral Diseases) 01/2022
1	Thymoma (Thymic Carcinoma) 11/2021
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2021
1	Lymphopenia (Lymphocytopenia) 01/2021
1	Waldenstrom Macroglobulinemia (Macroglobulinemia) 01/2021
1	Bacterial Infections (Bacterial Infection) 01/2020
1	Protozoan Infections 01/2019
1	Toxoplasmosis 01/2019
1	Blindness (Hysterical Blindness) 01/2019
1	Papilloma (Papillomatosis) 12/2018
1	Epidermodysplasia Verruciformis 12/2018
1	Leukopenia 01/2018
1	Atherosclerotic Plaque (Atheroma) 08/2011
1	Autosomal Recessive 3 Severe Congenital Neutropenia 10/2010
1	Graft vs Host Disease (Graft-Versus-Host Disease) 03/2010
1	Acquired Immunodeficiency Syndrome (AIDS) 07/2006
1	Myocardial Infarction 08/2005
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2003
1	Liver Diseases (Liver Disease) 02/2003
1	Hepatitis C 02/2003
1	Chronic Hepatitis C 02/2003

Drug/Important Bio-Agent (IBA)

14	Chemokine ReceptorsIBA 01/2021 - 04/2003
9	plerixafor FDA Link 10/2019 - 10/2010
6	ChemokinesIBA 03/2010 - 03/2002
2	VaccinesIBA 11/2021 - 04/2014
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2019 - 10/2010
2	GTP-Binding Proteins (G-Protein)IBA 01/2019 - 04/2014
2	LigandsIBA 01/2019 - 08/2011
2	Pharmaceutical PreparationsIBA 12/2018 - 07/2006
1	mRNA VaccinesIBA 11/2021
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2021
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021
1	Sirolimus (Rapamycin)FDA Link 01/2021
1	AntibodiesIBA 01/2021
1	MitogensIBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	CXCR4 Receptors (CXCR4 Receptor)IBA 10/2019
1	Pyrimethamine (Daraprim)FDA Link 01/2019
1	ArrestinIBA 01/2019
1	Retinaldehyde (Retinal)IBA 01/2019
1	Sulfadiazine (Sulphadiazine)FDA Link 01/2019
1	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 01/2019
1	Circular DNAIBA 12/2018
1	NucleotidesIBA 01/2016
1	Codon (Codons)IBA 01/2016
1	Immunoglobulins (Immunoglobulin)IBA 04/2014
1	Imiquimod (Aldara)FDA LinkGeneric 04/2014
1	CalciumIBA 07/2012
1	Amino Acids FDA Link 07/2012
1	ApolipoproteinsIBA 08/2011
1	Apolipoproteins E (ApoE)IBA 08/2011
1	Glucose (Dextrose)FDA LinkGeneric 10/2010
1	Glucose-6-PhosphateIBA 10/2010
1	EnzymesIBA 10/2010
1	HLA Antigens (Human Leukocyte Antigens)IBA 03/2010
1	CCR5 Receptors (CCR5 Receptor)IBA 01/2010
1	Angiotensin IIIBA 04/2007
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 08/2005
1	Chemokine CCL5IBA 02/2003
1	InterferonsIBA 02/2003
1	CCR ReceptorsIBA 02/2003

Therapy/Procedure

6	Therapeutics 01/2022 - 02/2003
4	Transplantation 01/2018 - 03/2002
2	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2018 - 01/2015
1	Hematopoietic Stem Cell Transplantation 01/2022
1	Precision Medicine 01/2019
1	Splenectomy 01/2018
1	Autologous Transplantation 01/2015
1	Hematopoietic Stem Cell Mobilization 04/2014